A Natural Flavonoid Ingredient for Sleep Support and Healthy Aging Formulations
As global attention on “healthspan” and “healthy aging” continues to grow, market demand for natural functional ingredients that combine scientific research with formulation potential is steadily increasing. As a natural flavonoid compound, apigenin has garnered widespread attention in recent years due to its associations with CD38, NAD+ metabolism, GABA_A receptors, and cellular health research, and has gradually become one of the key ingredients in the fields of functional foods, dietary supplements, and healthy aging formulations.
The apigenin raw material supplied by Shanghai Aidu Biotech is produced using a plant-derived semi-synthetic process. It utilizes Citrus aurantium L. extract as the precursor material and achieves high purity and stability control through precise separation and purification processes. Compared to traditional plant extraction methods, this production approach offers superior advantages in terms of purity consistency, impurity control, and scalable supply, meeting the demand for high-quality raw materials in the dietary supplement, functional food, and healthy nutrition formulation sectors.
| Test Item | Specification Standard | Test Method |
|---|---|---|
| Assay | 99.0% Min | HPLC |
| Loss on drying | 5.0% Max | USP |
| Ash | 1.0% Max | USP |
| Heavy metals | 10ppm Max | USP |
| As | 0.5ppm Max | USP |
| Pb | 0.5ppm Max | USP |
| Cd | 0.5ppm Max | USP |
| Hg | 0.1ppm Max | USP |
| Particle Size | 95% pass 80 mesh | USP |
| Bulk density | 0.18g/ml Min | USP |
| Total Plate Count | 1000 cfu/g Max | USP |
| Yeast & Mold | 100 cfu/g Max | USP |
Using Citrus aurantium L. extract as the precursor material, this product is manufactured through a semi-synthetic process combined with multi-step purification and crystallization. This ensures high purity and stability control, making it suitable for large-scale supply and high-standard quality management requirements.
95% of the product passes an 80-mesh sieve, with a bulk density of approximately 0.29 g/ml. It exhibits excellent flowability and dispersibility, making it suitable for the development of various dosage forms, including capsules, tablets, powders, gummies, and ready-to-drink (RTD) functional beverages.
Heavy metal and microbial limits comply with USP standards. We provide compliance declarations such as Non-GMO, Allergen-Free, and BSE/TSE-Free, meeting the quality management requirements of the dietary supplement and functional food sectors.
The product has low bitterness and minimal plant-derived off-flavors, helping to improve formulation palatability and reduce the complexity of flavor adjustment and masking system development. It is suitable for modern functional nutrition formulations.
Studies have shown that apigenin has certain associations with CD38 and NAD+ metabolic pathways. As a result, it has garnered significant attention in research on cellular energy metabolism, healthy aging, and mitochondrial function, and has been applied in the development of functional nutritional formulations.
Due to its association with GABA_A receptor research, apigenin is widely used in formulations for nighttime recovery, relaxation support, and sleep health, addressing modern consumers’ demand for gentle nighttime nutritional solutions.
Apigenin continues to attract attention in research areas related to cellular health, oxidative stress, and inflammatory balance. Its association with signaling pathways such as NF-κB makes it one of the most sought-after natural flavonoid ingredients in the fields of healthy aging, skin health, and functional nutrition.
Given the growing research interest in apigenin for healthy aging, nighttime recovery, cognitive health, and functional nutrition, it holds significant potential for application in dietary supplements and functional foods. The typical dosage in formulations is 50–100 mg per serving, though this can be adjusted based on the product’s specific positioning.
Suitable for the development of healthy aging nutritional formulations, cellular health support products, and NAD+ metabolism-related products.
Formulations: Capsules / Tablets / Powders / Functional Beverages
Suitable for products such as melatonin-free nighttime recovery gummies, relaxation support capsules, and evening nutritional powders.
Formulations: Gummies / Capsules / Powder sachets / RTD beverages
Suitable for the development of brain health, focus support, and modern functional nutrition formulations, applicable to daily cognitive health management products.
Formulations: Capsules / Tablets / Ready-to-drink products / Functional powders
Apigenin is CAS 520-36-5 (C15H10O5, MW 270.24), supplied at 99.0% minimum assay by HPLC as a light yellow fine powder.
It is produced by a semi-synthetic process from a plant-derived precursor — Citrus aurantium L. extract — followed by multi-step purification and crystallization, which gives better purity consistency and impurity control than conventional plant extraction.
Typical dosage is 50–100 mg per serving, adjusted according to the product's positioning.
Batch COA plus Non-GMO, allergen-free and BSE/TSE-free declarations; heavy metals and microbial limits meet USP standards. Contact idusc@aidubio.com for MOQ, pricing and delivery from our Los Angeles, CA warehouse.
Tell us the ingredient and volume you need. Our team will respond with pricing, lead time and documentation.
