Apigenin
01 · Cognitive & Brain Health

Apigenin

Apigenin | A Natural Flavonoid Ingredient for Sleep Support and Healthy Aging Formulations

Key Selling Points
  • Quality Control and Compliance Support
  • Mild Taste and Formulation Compatibility

02Product Description

Purity
99.0% Min
Appearance
Light yellow fine powder
CAS No.
520-36-5
Molecular Formula
C15H10O5
Molecular Weight
270.24

03Product Specifications

Test ItemSpecificationMethod
Assay99.0% Min / 100.0%HPLC
Loss on drying5.0% Max / 0.69%USP
Ash1.0% Max / 0.09%USP
Heavy metals10ppm Max / ConformsUSP
As0.5ppm Max / ConformsUSP
Pb0.5ppm Max / ConformsUSP
Cd0.5ppm Max / ConformsUSP
Hg0.1ppm Max / ConformsUSP
Particle Size95% pass 80 mesh / ConformsUSP
Bulk density0.18g/ml / 0.29g/mlUSP
Microbiology Control
Total Plate Count1000 cfu/g Max / ConformsUSP
Yeast & Mold100 cfu/g Max / ConformsUSP

04Product Process & Advantages

Semi-synthetic Process Using Plant-Derived Precursors

Using Citrus aurantium L. extract as the precursor material, this product is manufactured through a semi-synthetic process combined with multi-step purification and crystallization. This ensures high purity and stability control, making it suitable for large-scale supply and high-standard quality management requirements.

Excellent Physicochemical Properties and Formulation Compatibility

% of the product passes an 80-mesh sieve, with a bulk density of approximately 0.29 g/ml. It exhibits excellent flowability and dispersibility, making it suitable for the development of various dosage forms, including capsules, tablets, powders, gummies, and ready-to-drink (RTD) functional beverages.

Quality Control and Compliance Support

Heavy metal and microbial limits comply with USP standards. We provide compliance declarations such as Non-GMO, Allergen-Free, and BSE/TSE-Free, meeting the quality management requirements of the dietary supplement and functional food sectors.

Mild Taste and Formulation Compatibility

The product has low bitterness and minimal plant-derived off-flavors, helping to improve formulation palatability and reduce the complexity of flavor adjustment and masking system development. It is suitable for modern functional nutrition formulations.

05Product Functions & Mechanisms

Related to CD38 and NAD+ metabolism research

Studies have shown that apigenin has certain associations with CD38 and NAD+ metabolic pathways. As a result, it has garnered significant attention in research on cellular energy metabolism, healthy aging, and mitochondrial function, and has been applied in the development of functional nutritional formulations.

Formulation Development for Relaxation and Nighttime Recovery

Due to its association with GABA_A receptor research, apigenin is widely used in formulations for nighttime recovery, relaxation support, and sleep health, addressing modern consumers’ demand for gentle nighttime nutritional solutions.

Research on Cellular Health and Inflammatory Balance

Apigenin continues to attract attention in research areas related to cellular health, oxidative stress, and inflammatory balance. Its association with signaling pathways such as NF-κB makes it one of the most sought-after natural flavonoid ingredients in the fields of healthy aging, skin health, and functional nutrition.

06Applications

  • Given the growing research interest in apigenin for healthy aging, nighttime recovery, cognitive health, and functional nutrition, it holds significant potential for application in dietary supplements and functional foods. The typical dosage in formulations is 50–100 mg per serving, though this can be adjusted based on the product’s specific positioning.
  • Healthy Aging:
  • Suitable for the development of healthy aging nutritional formulations, cellular health support products, and NAD+ metabolism-related products.
  • Formulations: Capsules / Tablets / Powders / Functional Beverages
  • Sleep & Relaxation Support:
  • Suitable for products such as melatonin-free nighttime recovery gummies, relaxation support capsules, and evening nutritional powders.
  • Formulations: Gummies / Capsules / Powder sachets / RTD beverages
  • Cognitive Wellness:
  • Suitable for the development of brain health, focus support, and modern functional nutrition formulations, applicable to daily cognitive health management products.
  • Formulations: Capsules / Tablets / Ready-to-drink products / Functional powders
  • 六、Formulation Considerations
  • Healthy Aging Formulation
  • Applications: Healthy aging nutrition products / Cellular health support formulations / Functional nutritional supplements
  • Formulation Features: Suitable for product development in the areas of healthy aging and cellular health; can be combined with various functional nutritional ingredients to meet modern consumers’ needs for daily health management and functional nutritional support.
  • Melatonin-Free Nighttime Recovery
  • Recommended Combination: Apigenin + Magnesium (Magnesium Glycinate / Magnesium Threonate) + L-Theanine + GABA

07Packaging & Storage

  • Packaging specifications: Standard 25 kg cardboard drums (lined with double-layer moisture-proof PE bags); custom small-volume packaging for pilot testing and R&D is available.
  • Storage conditions: Keep tightly sealed and store in a cool, dry, well-ventilated area away from light, heat, and moisture.
  • Shelf life: 24 months.

08Frequently Asked Questions

What is the CAS number of Apigenin?

The CAS number of Apigenin is 520-36-5.

What purity of Apigenin do you supply?

AIDU Biotech supplies Apigenin at 99.0% Min, with full analytical data and a Certificate of Analysis (COA) for every batch.

Do you provide a COA and third-party testing for Apigenin?

Yes. Every batch of Apigenin ships with a complete Certificate of Analysis (COA), and we provide MSDS and third-party test reports on request.

Can you ship Apigenin from a US warehouse?

Yes. AIDU Biotech keeps inventory in our Los Angeles, USA warehouse for faster North American delivery, alongside global shipping from our own manufacturing facility.

What is the minimum order quantity (MOQ) for Apigenin?

MOQ and bulk pricing vary by grade and volume. Contact idusc@aidubio.com for free samples and a quote.

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+86-21-61049330 · +86-138-1774-6068
idusc@aidubio.com
Warehouse Address: Los Angeles, CA, USA

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