ProFisetin® Fisetin

Name: ProFisetin® Fisetin
Brand: AIDU Biotech

Nature's "Black Belt" Senolytic for Cellular Longevity & Systemic Renewal

Botanical Source: Cotinus coggygria

01Product Description

Nature’s "Black Belt" Senolytic for Cellular Longevity & Systemic Renewal

ProFisetin® is a high-purity natural fisetin developed and trademarked by Shanghai Aidu Biotechnology Co., Ltd. As a naturally occurring flavonoid, it is widely recognized by the scientific community as one of the most potent natural Senolytic agents available today.

02Core Technical Advantages

100% Natural Origin: Extracted from high-quality branches of Cotinus coggygria.
In-Vivo Verified Activity: Unlike raw materials supported only by in vitro tests, ProFisetin® is backed by complete zebrafish in-vivo study data confirming significant biological activity.
Ultra-High Purity Standard: Typical batch purity is stably above 98.5%, with heavy metal limits far stricter than California Proposition 65 requirements.
Compliant Manufacturing System: Produced under strict adherence to ISO9001/ISO22000, HACCP, and cGMP quality standards.
Full Range of Specifications: Diverse purity options to match different formulation needs:

03Standard Specifications: Fisetin 10%, 20%, 50%, 85%, 95%, 98% HPLC

Innovative Specification: Fisetin 10% HPLC Water-Soluble, solving the solubility challenge of fisetin in functional beverage applications.

04Scientific Mechanism: From Senolysis to Bioenergetic Optimization

As a pleiotropic bioactive ingredient, the biological effects of ProFisetin® have been extensively documented in authoritative journals including Nature Aging, The Lancet, and Frontiers in Chemistry.

Advanced Senolytic Mechanism

ProFisetin® effectively modulates anti-apoptotic signaling pathways such as PI3K/Akt/mTOR, selectively guiding non-dividing senescent cells into natural apoptosis. It significantly reduces systemic inflammatory cytokine storms and creates space for tissue regeneration.

Vascular Endothelial Support

Recent preclinical studies show ProFisetin® intervenes in aortic sclerosis, protects vascular endothelial diastolic function by reducing oxidative damage to vessel walls, and emerges as a key novel ingredient for cardiovascular longevity interventions.

Neuro-Pathway Preservation

By enhancing the expression of Brain-Derived Neurotrophic Factor (BDNF), ProFisetin® stimulates Long-Term Potentiation (LTP). It protects brain cells from stress damage while maintaining cognitive resilience in the central nervous system.

Bioenergetic Optimization

As a mitochondrial protector, it effectively stabilizes mitochondrial membrane potential and clears excess intracellular Reactive Oxygen Species (ROS), ensuring efficient cellular energy output even under metabolic stress.

05Exclusive Bioactivity Validation: Zebrafish In-Vivo Study

Conclusion: ProFisetin® demonstrates statistically significant antioxidant efficacy.

In ROS fluorescence intensity assessments using AB-strain zebrafish:

Efficacy Data: ProFisetin® significantly reduced intracellular ROS fluorescence intensity by 16.95% compared to the blank control group.
Statistical Significance: P-value = 0.0278 (P < 0.05), confirming high and stable biological activity.
Safety: Maximum Tolerated Concentration (MTC) established at 200 μg/mL, with no adverse effects observed at this dose.

06Technical Specifications

*Based on typical batch data for 98% HPLC-AREA grade

Item	Specification	Test Method
Purity (Fisetin)	98.0% Min	HPLC-AREA
Assay (Fisetin)	85.0% Min	External HPLC
Loss on drying	5.0% Max	USP
Ash	5.0% Max	USP
Particle Size	100% pass 80 mesh	USP
Heavy metals	10ppm Max	USP
Pb	0.5ppm Max	USP
As	1ppm Max	USP
Hg	0.1ppm Max	USP
Cd	0.5ppm Max	USP
Residual	5000ppm Max	GC
solvent (Ethanol)	0.2g/ml Min	USP
Bulk density	0.3g/ml Min	USP
Total Plate Count	1000cfu/g Max	USP
Mold and yeast	100cfu/g Max	USP

07Application Directions & Solutions

High-End Anti-Aging Formulations: 95%–98% high-purity powder for precision longevity capsules and tablets.

Innovative Functional Beverages: 10% HPLC water-soluble grade with high clarity and stability after dissolution, suitable for functional drinks, oral liquids, and solid beverages.

Sports Nutrition & Metabolic Support: Enhances athletic performance and supports weight management by optimizing mitochondrial function.

08Compliance & Global Supply

Certification System: ISO9001/ISO22000, HACCP, cGMP, Kosher, SGS Verified

Clean Label: Non-GMO, BSE/TSE Free, ETO Free, Allergen Free

Global Logistics: In-stock warehouses in China and the USA, supporting 100% traceable delivery

U.S. Trademark & Commercial Compliance:

Official Trademark Registration: Protected under U.S. Trademark Serial No. 98568732 by Shanghai Aidu Biotechnology Co., Ltd.

Proven Commercialization: Successfully introduced and actively commercialized in U.S. commerce since March 26, 2025, offering verified batch consistency and regulatory peace of mind for global brand formulators.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. For B2B commercial use only.

09Frequently Asked Questions

What purity grades of ProFisetin® are available?

Standard grades are Fisetin 10%, 20%, 50%, 85%, 95% and 98% HPLC, plus an innovative 10% HPLC water-soluble grade for beverage systems. Typical batch purity of the 98% grade is stably above 98.5%.

Can you provide a COA and third-party test reports?

Yes. Every shipment includes a batch-specific COA covering assay, heavy metals, residual solvents and microbiology. The material is produced under ISO9001/ISO22000, HACCP and cGMP systems and is SGS verified; additional third-party reports are available on request.

Do you stock ProFisetin® in the United States?

Yes. We hold ready stock in both China and our U.S. warehouse in Los Angeles, CA, with 100% traceable delivery for domestic orders.

What is the MOQ and how do I get a quotation?

MOQ and pricing depend on grade and volume; small R&D quantities and full 25 kg drums are both supported. Contact idusc@aidubio.com with your target grade and annual volume for a quotation and free sample.