Spermidine trihydrochloride is the hydrochloride salt form of spermidine, a naturally occurring polyamine found in living organisms. It plays an essential role in cellular physiological processes and has been extensively studied for its involvement in cellular homeostasis and autophagy-related pathways. Compared to free-base spermidine, the trihydrochloride form offers enhanced chemical stability, improved handling characteristics, and greater suitability for industrial-scale formulation, making it an ideal raw material for dietary supplements, functional foods, and research applications.
| Test Item | Specification | Method |
|---|---|---|
| Purity | 99.0% Min | GC |
| Solubility | Soluble in water / USP<1236> | |
| Loss on drying | 1.0% Max / USP<731> | |
| Residue on ignition | 0.2% Max / USP<281> | |
| Heavy Metals | 10ppm Max / USP<233> | |
| Pb | 0.5ppm Max / USP<233> | |
| As | 0.15ppm Max / USP<233> | |
| Hg | 0.1ppm Max / USP<233> | |
| Cd | 0.5ppm Max / USP<233> | |
| Microbiology Control | ||
| Total Plate Count | 1000cfu/g Max / USP<61> | |
| Yeast&Mold | 100cfu/g Max / USP<61> | |
Achieves overall purity ≥99% through multi-stage recrystallization, with impurity levels significantly below industry standards.
Pure white powder with no noticeable odor; produced via green synthesis, non-GMO, allergen-free, and gluten-free, meeting global clean-label and compliance requirements.
The HCl salt form provides greater chemical stability and antioxidant capacity compared to free base, ideal for dietary supplement formulation development and long-term storage.
In-house facilities strictly follow cGMP standards and are certified by ISO 9001:2015, HALAL, KOSHER, and other international authorities, ensuring full regulatory compliance worldwide.
Vertically integrated from R&D to production, supported by strategic U.S.-based warehousing, enabling reliable bulk supply and rapid delivery.
Spermidine is one of the most potent natural inducers of autophagy known to date. It activates cellular self-cleaning mechanisms to remove damaged mitochondria and proteins, thereby maintaining cellular homeostasis.
Helps improve vascular elasticity, supports heart health, and reduces age-related cardiovascular stress.
Protects against neuronal damage and helps maintain cognitive sharpness and memory during aging.
Works synergistically with NAD+ and NMN to comprehensively optimize metabolic and longevity pathways in the body.
Evidence from ResearchA long-term prospective cohort study published in 2018 investigated the potential association between dietary spermidine intake and all-cause mortality. The study followed 829 participants aged 45 to 84 over a period of 20 years, analyzing their habitual dietary spermidine intake and mortality outcomes.Participants were categorized into three groups based on daily spermidine intake: low intake (< 62.2 μmol/day), moderate intake (62.2–79.8 μmol/day), and high intake (> 79.8 μmol/day). During the follow-up, a total of 341 deaths were recorded, including 137 cardiovascular-related deaths, 94 cancer-related deaths, and 110 deaths from other causes.
The crude mortality rates observed across the low-, moderate-, and high-intake groups were 40.5%, 23.7%, and 15.1%, respectively. These findings indicate a significant inverse association between dietary spermidine intake and all-cause mortality.
The mortality risk difference between individuals with the highest and lowest spermidine intake mirrors the survival advantage associated with being 5.7 years younger, providing evidence that long-term spermidine consumption contributes to longevity.*Data source: Kiechl, S., Pechlaner, R., Willeit, P., et al. (2018). Higher spermidine intake is linked to lower mortality: a prospective population-based study. The American Journal of Clinical Nutrition, 108(2), 371–380. https://doi.org/10.1093/ajcn/nqy102
The CAS number of Spermidine Trihydrochloride is 334-50-9.
AIDU Biotech supplies Spermidine Trihydrochloride at 99.0% Min, with full analytical data and a Certificate of Analysis (COA) for every batch.
Yes. Every batch of Spermidine Trihydrochloride ships with a complete Certificate of Analysis (COA), and we provide MSDS and third-party test reports on request.
Yes. AIDU Biotech keeps inventory in our Los Angeles, USA warehouse for faster North American delivery, alongside global shipping from our own manufacturing facility.
MOQ and bulk pricing vary by grade and volume. Contact idusc@aidubio.com for free samples and a quote.
Tell us the ingredient and volume you need. Our team will respond with pricing, lead time and documentation.
