| Test Item | Specification | Method |
|---|---|---|
| Purity | 99.58% | HPLC |
| Assay(Dry Basis) | 99.02% | HPLC |
| Sodium Content | 5.5%-7.5% | |
| IC | ||
| Water | 1.47% | KF |
| PH | 8.6 | |
| PH meter | ||
| Pb | 1ppm Max | ICP-MS |
| As | 1ppm Max | ICP-MS |
| Hg | 0.1ppm Max | ICP-MS |
| Cd | 0.5ppm Max | ICP-MS |
| Heavy Metals | 10ppm Max | ICP-MS |
| Microbiology Control | ||
| Total Plate Count | 1000cfu/g Max | GB4789.2 |
| Moulds & Yeast | 100cfu/g Max | GB4789.15 |
AIDU uses a proprietary enzymatic method mimicking natural pathways to produce NADH with high purity, zero heavy metal residues, and no by-products—cleaner and more sustainable than chemical synthesis.
The overall production workflow includes:Enzymatic conversion → Enzyme removal → Concentration → Desalination → Reconcentration → Crystallization → Centrifugation → Drying → Metal detection → Packaging
Advanced crystallization and moisture control technologies ensure the product remains chemically stable under ambient storage, simplifying formulation into capsules, tablets, or powders.
Manufactured in a cGMP/ISO9001-certified facility with SSC22000, HALAL, and KOSHER certifications—meeting global quality and food safety standards.
From enzyme development to final production, AIDU controls the entire supply chain, offering competitive pricing and stable supply while mitigating raw material fluctuations.
Multi-stage purification guarantees >98% purity with absorbance ratios that meet international pharmacopoeia standards, ensuring safety and efficacy for nutraceutical applications.
NADH directly donates electrons to Complex I of the mitochondrial electron transport chain, facilitating ATP synthesis and enhancing cellular bioenergetics. As a core molecule in mitochondrial energy metabolism, NADH participates in Complex I of the electron transport chain, directly powering ATP synthesis. Studies have demonstrated that restoring the mitochondrial NADH oxidation capacity via NDI1 (NADH dehydrogenase) can significantly improve the cellular energy metabolic state [1, 9]. The mitochondrial electron transport chain couples NADH oxidation with proton pumping across the inner membrane, and the resulting electrochemical gradient is utilized by H+-ATP synthase to synthesize ATP [9]. When each molecule of NADH is oxidized within mitochondria, it drives the production of multiple ATP molecules, serving as the "powerhouse" of cellular energy.
NADH plays a pivotal role in regulating the intracellular NAD⁺/NADH ratio, supporting oxidative stress management, and providing cellular protection. The intracellular NAD⁺/NADH ratio is crucial for the regulation of redox reactions, and the balance between these two forms is essential for efficient energy metabolism, being regulated by the activity of lactate dehydrogenase, the malate-aspartate shuttle, and the glycerol-3-phosphate shuttle [7]. Studies have shown that dysregulation of the NAD⁺/NADH ratio is closely associated with the aging process, including age-related neurodegenerative diseases and progressive cognitive decline [7].
Research in Arabidopsis thaliana has revealed that the mitochondrial glycerol-3-phosphate shuttle is involved in maintaining cellular redox homeostasis, with mutants exhibiting an elevated NADH/NAD⁺ ratio and altered reactive oxygen species (ROS) homeostasis [2]. Preserving the NAD⁺/NADH balance is vital for the cellular antioxidant defense mechanisms, the maintenance of calcium homeostasis, and cell survival.
NADH participates in neurotransmitter synthesis pathways and has been incorporated into formulation research aimed at enhancing mental clarity and alleviating fatigue. NAD⁺ and its reduced form, NADH, are of particular importance to brain cells, as the central nervous system heavily relies on ATP availability to maintain brain plasticity [7]. NAD⁺, NADH, and their metabolites exert significant effects on synaptic plasticity, cell death, neurogenesis, angiogenesis, as well as intercellular communication and the rearrangement of intracellular signaling pathways [7].A double-blind, placebo-controlled clinical study demonstrated that stabilized NADH (20mg sublingual tablet) effectively improved cognitive decline and drowsiness induced by jet lag. Subjects receiving NADH performed significantly better than the placebo group on four cognitive test indicators (P ≤ 0.05), with no adverse effects observed [3]. This clearly indicates the clinical application potential of NADH in improving cognitive function and alleviating fatigue.
NADH supports endurance and post-exercise recovery by enhancing mitochondrial efficiency. Research has shown that the combination of nicotinamide riboside (NR) supplementation and Zone 2 training may enhance mitochondrial function and aerobic adaptability by elevating NAD⁺ levels [4]. Mitochondria, as core organelles, are responsible for providing ATP to meet the bioenergetic demands of cells, a role that is particularly crucial during exercise. Endurance exercise improves overall aerobic capacity by promoting mitochondrial biogenesis [8].In mouse models, supplementation with NAD⁺-boosting compounds significantly increased the content of both NAD⁺ and NADH (by 29-42% and 72-39% respectively), while also improving mitochondrial function, promoting carbohydrate utilization, and enhancing metabolic flexibility [8]. These findings support the application potential of NADH in sports nutrition, as it enhances endurance and post-exercise recovery through the optimization of mitochondrial function.
NADH is frequently combined with other metabolic and mitochondrial support ingredients to enhance formulation synergy.
Common formulation partners include:
PQQ (Pyrroloquinoline Quinone) – mitochondrial biogenesis
Alpha-Lipoic Acid (ALA) – antioxidant and metabolic support
HYPERLINK "https://www.aidubio.com/product/-nicotinamide-mononucleotide-nmn-185.html" \t "_blank"NMN / NR – NAD⁺ metabolism support
The CAS number of β-Nicotinamide adenine dinucleotide disodium salt (NADH) is 606-68-8.
AIDU Biotech supplies β-Nicotinamide adenine dinucleotide disodium salt (NADH) at 99.58%, with full analytical data and a Certificate of Analysis (COA) for every batch.
Yes. Every batch of β-Nicotinamide adenine dinucleotide disodium salt ships with a complete Certificate of Analysis (COA), and we provide MSDS and third-party test reports on request.
Yes. AIDU Biotech keeps inventory in our Los Angeles, USA warehouse for faster North American delivery, alongside global shipping from our own manufacturing facility.
MOQ and bulk pricing vary by grade and volume. Contact idusc@aidubio.com for free samples and a quote.
Tell us the ingredient and volume you need. Our team will respond with pricing, lead time and documentation.
