Dedicated to pure natural cellular repair, redefining the source of longevity
Supermidine™ is a star ingredient developed by Aidu Biotech, tailored for the global longevity management market. We remain committed to direct extraction from premium non-GMO wheat germ, fully preserving the original structure of the plant's natural active molecules. As a potent autophagy inducer, spermidine leverages a cellular "clean-up" mechanism to efficiently eliminate damaged proteins, standing as a cutting-edge core ingredient in the fields of anti-aging, immune support, and metabolic management today.
Golden Specifications: Available in multiple specifications, including 0.2%, 0.5%, and 1% Min.
Pure Natural Commitment: The core 1.0% specification is 100% derived from pure natural extraction from wheat germ, not synthetically produced. It boasts higher bioavailability and perfectly meets the strict demands of high-end brands for "Clean Label" and natural health.
Comprehensive Testing Coverage: Equipped with an independent laboratory, we conduct strict testing on core indicators such as content (GC/HPLC), microorganisms, and heavy metals.
Authoritative Report Endorsement: Each batch is accompanied by a detailed independent Certificate of Analysis (COA) with the shipment, ensuring that the residues of heavy metals (lead, arsenic, mercury, cadmium) and pathogenic bacteria are far below international general standards, supporting global traceability and auditing.
Stable Characteristics: Presented as a brownish-yellow powder with uniform particles, it features excellent fluidity and solubility.
Strong Compatibility: It performs exceptionally when compounded with ingredients like NMN and Ergothioneine (RejuEGT®), and is suitable for various dosage forms such as capsules, tablets, and powders.
The core mechanism of Supermidine™ is to induce autophagy — a physiological process of cellular self-cleansing, renewal and repair. With aging, autophagy function declines, leading to the accumulation of damaged cells and chronic inflammation, also known as inflammaging.
Spermidine induces the formation of autolysosomes by inhibiting EP300 acetyltransferase and other non-mTOR-dependent pathways, thereby promoting the clearance of intracellular waste components.
It facilitates the removal of dysfunctional mitochondria, reduces the leakage of mitochondrial reactive oxygen species (mtROS), and preserves the integrity of mitochondrial DNA.
Downregulates the levels of key inflammatory factors such as IL-6 and TNF-α, alleviating systemic low-grade chronic inflammation — the core driving factor of inflammaging.
By mitigating oxidative stress and inflammation, it indirectly maintains NAD⁺ metabolic homeostasis and exerts a synergistic effect with NAD⁺ precursors such as NMN.
*Based on typical batch results for 1.0% grade
| Item | Specification | Text Method |
|---|---|---|
| Assay (Spermidine) | 1.0% Min | GC |
| Loss on drying | 7.0% Max | USP<731> |
| Ash | 5.0% Max | USP<281> |
| Particle Size | 95% pass 80 mesh | USP<786> |
| Pb | 2ppm Max | ICP-MS |
| As | 2ppm Max | ICP-MS |
| Hg | 0.1ppm Max | ICP-MS |
| Cd | 1ppm Max | ICP-MS |
| Bulk density | 0.4-0.6g/ml | USP |
| Mesh | 0.7-0.9g/ml | USP |
| Total Plate Count | 1000cfu/g Max | AOAC |
| Mold and yeast | 100cfu/g Max | AOAC |
Supermidine™ exerts potent effects on autophagy activation and inflammation reduction, providing strong support for formula development across four major health segments:
Synergy Recommendations: NMN, Resveratrol, Coenzyme Q10
Applicable Dosage Forms: Capsules, tablets, stick powder
Synergy Recommendations: Biotin, Collagen Peptide, Vitamin C, RejuEGT® (Ergothioneine)
Applicable Dosage Forms: Liquid drinks, gummies, tablets
Synergy Recommendations: PS (Phosphatidylserine), GABA (Gamma-Aminobutyric Acid), Ginkgo Biloba, DHA
Applicable Dosage Forms: Capsules, functional foods
Synergy Recommendations: Leucine, BCAA (Branched-Chain Amino Acids), Glutamine
Applicable Dosage Forms: Recovery drinks, powder, tablets
Certification System: ISO9001, ISO22000, Kosher, EU Novel Food Compliance
Clean Label: Non-GMO, consistent batch supply, traceable production
Global Supply: Supports long-term stable supply and customized requirements for international markets
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. For B2B commercial use only.
The core 1.0% specification is 100% naturally extracted from non-GMO wheat germ (Triticum aestivum), not synthetic — supporting clean-label and natural-origin claims.
Spermidine content of 0.2%, 0.5% and 1.0% Min, assayed by GC. Other strengths can be discussed for contract volumes.
Each batch ships with an independent Certificate of Analysis covering content, microbiology and heavy metals (Pb, As, Hg, Cd), supporting global traceability and audits. ISO9001/ISO22000, Kosher and EU Novel Food compliance documents are available.
Yes, material is available from our Los Angeles, CA warehouse as well as from China. Email idusc@aidubio.com with your target specification and volume for MOQ, pricing and samples.
Tell us the ingredient and volume you need. Our team will respond with pricing, lead time and documentation.
