Calcium Alpha Ketoglutarate (Ca-AKG) is a natural bioactive compound, serving as the calcium salt form of endogenous α-ketoglutarate (AKG). It ingeniously integrates the core metabolic regulatory function of the tricarboxylic acid (TCA) cycle with the bone-nourishing benefits of calcium.
| Test Item | Specification | Method |
|---|---|---|
| Purity | 99.6% / HPLC / Ca2+ / 20.4% | |
| USP-NF | ||
| Loss on drying | 0.46% | |
| USP-NF | ||
| Heavy metals | 10ppm Max | |
| USP-NF | ||
| Pb | 0.5ppm Max | |
| USP-NF | ||
| As | 1ppm Max | |
| USP-NF | ||
| Hg | 0.1ppm Max | |
| USP-NF | ||
| Cd | 0.5ppm Max | |
| USP-NF | ||
| Microbiology Control | ||
| Total Plate Count | 1000cfu/g Max | |
| USP-NF | ||
| Mold & Yeast | 100cfu/g Max | |
| USP-NF | ||
We employ bio-fermentation technology combined with precise calcium salt complexation processes, replacing traditional chemical synthesis at the source to achieve genuine "green production":
Thoroughly eliminates heavy metal residues and by-product contamination, ensuring the product has excellent biocompatibility.
From strain selection, fermentation, to drying and crystallization, the entire process strictly adheres to GMP standards.
Has passed FSSC22000, HALAL, and KOSHER certifications, with quality meeting the access standards of multiple regions worldwide.
High Purity and High Activity, Quality Aligned with International Standards: Relying on multi-stage purification technology, the Ca-AKG provided by Aidu demonstrates extremely high biological activity:
The main component content is no less than 98%, and the calcium content is precisely controlled at 18-21%.
With a pH value in the range of 6-8 (neutral to weakly alkaline), it has outstanding stability and is easy for long-term storage.
The active ingredients can quickly act on target organs such as bones and muscles, with bioavailability exceeding that of single AKG.
Diverse Application Scenarios and Strong Formula Compatibility: As a white/off-white powder, Ca-AKG has extremely high production adaptability. Its property of being slightly soluble in water meets the R&D needs of solid preparations such as capsules, tablets, and powders; it can be synergistically combined with various functional ingredients like vitamins, collagen, and amino acids without compatibility contraindications; it can meet the concentration, solubility, and functional requirements of different fields such as dietary supplements, sports nutrition, functional foods, and animal health, providing sufficient flexibility for formula development.
Prominent Cost Advantages and Excellent Cost-Effectiveness: Compared with single anti-aging or calcium-supplementing ingredients, Ca-AKG offers a more cost-effective solution:
Achieves the dual effects of "metabolic regulation + mineral supplementation" within a single ingredient.
Relying on a mature industrialization base, it ensures stable production capacity and significantly reduces customers' R&D and investment costs.
Empowered by Slow-release Technology, Delivering Superior Bioavailability
Unlike ordinary AKG, Ca-AKG (Calcium Alpha Ketoglutarate) possesses a natural slow-release property. Its molecular structure enables the steady and gradual release of active ingredients in the intestine, effectively preventing drastic fluctuations in blood drug concentrations.
It extends the circulation time of active ingredients in the body, ensuring that cells can continuously take up α-ketoglutarate, and its bioavailability significantly outperforms traditional forms.
Reversing Biological Age, Initiating Deep Epigenetic Regulation
Ca-AKG is one of the few substances currently clinically verified to intervene in the "biological clock".
Animal experiments published in top journals such as Cell Metabolism and Aging Cell, as well as the Rejuvenation clinical study, have confirmed that Ca-AKG, as a core cofactor of TET enzymes, can reset the epigenetic markers associated with aging by precisely regulating the DNA methylation pattern.
Animal experiment results showed that the epigenetic age of mice in the intervention group decreased by an average of 9.2 months, the median lifespan was extended by 9.6%-19.7%, and the frailty index was significantly reduced.
Activating Cellular Autophagy for In-depth Mitochondrial Cleanup
Ca-AKG serves as a potent inducer of cellular autophagy, capable of initiating the body's innate "cleanup mechanism."
By continuously stimulating autophagy (Autophagy), it accelerates the clearance of damaged proteins and dysfunctional mitochondria within cells, optimizes the cellular metabolic environment, and prevents functional decline caused by cellular aging.
Building a Solid Defense for Muscles and Bones
Ca-AKG offers dual metabolic support for the elderly and sports enthusiasts.
As a key intermediate in ammonia metabolism, Ca-AKG efficiently converts accumulated ammonia in the body to maintain nitrogen balance. It not only enhances athletic endurance but also demonstrates remarkable effectiveness in preventing age-related muscle atrophy (Sarcopenia).
Beyond supplementing calcium, Ca-AKG regulates the AMPK and mTOR pathways, activating autophagy in chondrocytes while suppressing inflammatory stress responses. With this multi-dimensional mechanism, it effectively alleviates joint degeneration, providing more comprehensive bone health protection for postmenopausal women and the elderly.
The current market trend has comprehensively shifted from "single-ingredient" to "multi-target synergy." Below are several popular formula combinations favored in 2026:
The CAS number of Calcium α-ketoglutaric acid (AKG-CA) is 71686-01-6.
AIDU Biotech supplies Calcium α-ketoglutaric acid (AKG-CA) at 99.6%, with full analytical data and a Certificate of Analysis (COA) for every batch.
Yes. Every batch of Calcium α-ketoglutaric acid ships with a complete Certificate of Analysis (COA), and we provide MSDS and third-party test reports on request.
Yes. AIDU Biotech keeps inventory in our Los Angeles, USA warehouse for faster North American delivery, alongside global shipping from our own manufacturing facility.
MOQ and bulk pricing vary by grade and volume. Contact idusc@aidubio.com for free samples and a quote.
Tell us the ingredient and volume you need. Our team will respond with pricing, lead time and documentation.
