α-Ketoglutaric acid (AKG) is a naturally occurring intermediate in the Krebs cycle (TCA cycle), which serves as the core metabolic pathway responsible for cellular energy production.
| Test Item | Specification | Method |
|---|---|---|
| Assay | 99.9% | HPLC |
| Transmittance | 99.2% | HPLC |
| Loss on drying | 0.15% | |
| USP-NF | ||
| Residue on ignition | 0.04% | |
| USP-NF | ||
| Cl- | 200ppm Max | |
| USP-NF | SO42- / 200ppm Max | |
| USP-NF | ||
| As | 1ppm Max | |
| USP-NF | Fe3+ / 0.1ppm Max | |
| USP-NF | ||
| Heavy Metals | 10ppm Max | |
| USP-NF | ||
| Microbiology Control | ||
| Total Plate Count | 1000cfu/g Max | |
| USP-NF | ||
| Mold & Yeast | 100cfu/g Max | |
| USP-NF | ||
Adopting a bio-fermentation process to replace traditional chemical synthesis, it eliminates heavy metal residues and by-product contamination at the source. The product is homologous to the endogenous AKG in the human body, ensuring excellent biocompatibility.
The entire production process strictly adheres to GMP standards, covering the full chain from strain screening → fermentation conversion → extraction and refining → purification and impurity removal → drying and crystallization → testing and analysis → finished product packaging. The industrialization base is equipped with advanced fermentation and purification equipment as well as precision testing instruments. It has established four major technical platforms: synthetic biology R&D, application mechanism R&D, microbial fermentation, and analysis and testing, achieving full-chain quality control from raw materials to finished products. The product has successfully passed multiple internationally authoritative certifications, including FSSC22000, HALAL, and KOSHER.
High Purity and High Activity, Quality Meets International Standards: Achieving high product purity through a multi-stage purification process, the content of the main component reaches 99.9%. All physical, chemical, and microbial indicators far exceed industry standards, ensuring strong biological activity.
Stable Physicochemical Properties, Strong Compatibility: The product is in a stable powder form, making it easy to store and process. Different derivative categories (pure product, calcium salt, arginine complex) can be flexibly formulated according to application scenarios, precisely meeting the concentration, solubility, and functional requirements of various fields such as dietary supplements, cosmetics, and food additives.
Extensive Scientific Research, Authoritative Efficacy Support: With over 400 research papers published in international core medical journals such as Nature, Cell, and Aging, and 12 human clinical trials validating its efficacy, the product's benefits cover nine major health fields including anti-aging, sports nutrition, and bone health, with a thorough understanding of its mechanism of action.
Significant Cost Advantage, Outstanding Cost-effectiveness: Leveraging mature industrial fermentation technology and large-scale production capabilities, it offers lower application costs compared to similar anti-aging and nutritional supplement ingredients while ensuring comprehensive efficacy, significantly reducing the product development and production investment for downstream customers.
As a core component of the tricarboxylic acid (TCA) cycle, α-ketoglutarate serves as a critical hub in the body's metabolism. It exerts physiological functions by regulating multiple dimensions, ranging from cellular energy metabolism and gene expression to substance synthesis. Its core mechanisms of action center on energy metabolism, protein synthesis, and redox balance. The specific functions are as follows:
Support Cellular Energy Metabolism, Boost Body Vitality
AKG can freely diffuse across the outer mitochondrial membrane and traverse the inner mitochondrial membrane via the malate-aspartate shuttle system. It directly participates in the tricarboxylic acid (TCA) cycle to supply energy to cells, bypassing the preparatory stages of glycolysis and the TCA cycle, thereby greatly enhancing the body's metabolic efficiency. Meanwhile, as a precursor to glutamine and glutamate, it ensures the normal operation of cells in the liver, kidneys, intestines, as well as the immune system and neurons.
Additionally, AKG can activate the AMPK signaling pathway, reduce muscle energy expenditure, promote fat metabolism, increase the body's energy reserves, and thus improve the overall energy state.
AKG can significantly suppress the expression of mTOR and the activity of ATP synthase, downregulate aging-related signaling pathways, and reduce the release of chronic inflammatory factors, thereby delaying cellular senescence. Human clinical trials have demonstrated that daily supplementation with an appropriate amount of AKG can reduce the biological aging age by an average of nearly 7.8 years, effectively mitigating age-related physiological decline. Moreover, AKG can enhance the telomere maintenance system, inhibit reproductive aging, restore ovarian reserve and fertility, and delay the age-related decline in the quality and quantity of oocytes.
α‐ketoglutarate delays age‐related fertility decline in mammals
Promote Protein Synthesis, Enhance Muscle Growth and Fat Loss, and Improve Athletic Performance
As a precursor to glutamine, AKG supplies raw materials for the synthesis of non-essential amino acids, driving the process of protein synthesis in the body. Meanwhile, through the PHD3/ADRB2 pathway, it prevents skeletal muscle protein degradation, reduces the risk of muscle atrophy, and thus increases muscle mass and strength;
AKG activates adrenal signaling pathways to enhance thermogenesis
and lipolysis, thereby supporting weight loss and metabolic regulation.
It can specifically promote brown fat formation, activate the OXGR1-dependent adrenal pathway, reduce white fat accumulation, shrink adipocyte volume, and effectively prevent diet-induced obesity. In the field of sports, AKG can enhance maximal aerobic power, reduce post-exercise lactic acid buildup, extend endurance exercise duration, improve anaerobic strength and jumping ability, while preventing the risk of post-exercise ammonia poisoning and accelerating post-exercise recovery.
AKG can regulate histone methylation, promote the proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cells, increase bone mass in the elderly, and accelerate bone tissue regeneration. It can lower the level of C-terminal telopeptide of type I collagen (CTX) in the serum of postmenopausal women, enhance lumbar spine bone mineral density, and inhibit bone resorption and mineral loss. Meanwhile, AKG promotes chondrocyte metabolism, facilitates the accumulation of extracellular matrix, and reduces the toxicity caused by ammonia accumulation in the culture medium, comprehensively protecting bone and joint health.
Empower Body Health in Multiple Dimensions and Optimize Physiological State
The CAS number of α-Ketoglutaric Acid (AKG) is 328-50-7.
AIDU Biotech supplies α-Ketoglutaric Acid (AKG) at 99.9%, with full analytical data and a Certificate of Analysis (COA) for every batch.
Yes. Every batch of α-Ketoglutaric Acid ships with a complete Certificate of Analysis (COA), and we provide MSDS and third-party test reports on request.
Yes. AIDU Biotech keeps inventory in our Los Angeles, USA warehouse for faster North American delivery, alongside global shipping from our own manufacturing facility.
MOQ and bulk pricing vary by grade and volume. Contact idusc@aidubio.com for free samples and a quote.
Tell us the ingredient and volume you need. Our team will respond with pricing, lead time and documentation.
