L-5-Methyltetrahydrofolate Calcium (L-5-MTHF-Ca)
| Test Item | Specification | Method |
|---|---|---|
| Assay(on dry basis) | 95.0%~102.0% / HPLC / L-5-MTHF / 72.0%~95.0% | |
| Calculation | ||
| Calcium(on dry basis) | 7.0%~8.5% / USP43 | |
| Water Content | 6.0%-17.0% | |
| Karl Fischer | ||
| Platinum | 10ppm Max / USP43 | |
| Boron | 50ppm Max / USP43 | |
| Chloride | 0.5%Max / USP43 | |
| Heavy Metals | 10ppm Max / USP<231> | |
| Pb | 1.0ppm Max | ICP-MS |
| As | 1.0ppm Max | ICP-MS |
| Hg | 0.1ppm Max | ICP-MS |
| Cd | 0.5ppm Max | ICP-MS |
| Microbiology Control | ||
| Total Plate Count | 1000cfu/g Max / USP43 | |
| Mold & Yeast | 100cfu/g Max / USP43 | |
We adopt an advanced process combining chemical synthesis and biocatalysis to ensure the product's high bioavailability from the molecular source.
Highly Selective BioreductionThrough patented catalytic reduction technology, folic acid is precisely converted into the bioactive L-configuration (levorotatory) structure. This fundamentally eliminates interference from inactive isomers and significantly enhances human absorption efficiency.
Calcium Salt Crystal Stabilization TechnologyBy introducing calcium ions to form a stable calcium salt crystal structure, we effectively overcome the technical challenges of easy oxidation and extreme instability in active folate. This greatly extends the product's shelf life and storage stability.
Purification and Quality Control, Benchmarking Top International Standards
We employ a dual purification technology of multi-stage recrystallization plus ion exchange to precisely remove the inactive D-isomer. It meets the requirements of high-end formulations in Europe and America, with extremely low impurities.
We implement a full closed-loop control from raw materials to packaging, supporting FSSC22000 / HALAL / KOSHER certifications.
Direct Supply Model, Long-term Empowerment
As a source manufacturer with large-scale production capacity, we provide you with more competitive cooperation solutions.
Leveraging the economies of scale of our own factory, we eliminate middleman markups, offering significant cost advantages.
Our own production lines ensure sufficient capacity, effectively resisting market fluctuation risks and guaranteeing long-term spot supply.
We flexibly support customized needs, making us an ideal partner for long-term brand contract manufacturing and formulation development.
Stable large-scale production capacity with consistent quality
Strict multi-level quality control with authoritative international certifications
Customized product solutions for diverse application scenarios
As a core cofactor in one-carbon metabolism, L-5-MTHF plays a critical role in the methylation cycle:
Genetic polymorphisms of L-5-methyltetrahydrofolate reductase (MTHFR) and implication in methotrexate depletion of systemic folate.
Efficient Anemia Correction and DNA Synthesis:
As illustrated, 5-MTHF is the active endpoint of folate metabolism. It bypasses complex enzymatic reactions to directly supply one-carbon units, ensuring DNA synthesis at the source and preventing anemia.
Regulation of Homocysteine (Hcy) Levels:
L-5-MTHF acts as a methyl donor, promoting the conversion of Hcy into methionine, thereby lowering the risks of cardiovascular diseases and pregnancy-induced hypertension.
L-5-MTHF bypasses metabolic barriers, supporting DNA synthesis to prevent NTDs while directly lowering Hcy levels.
Preconception and Pregnancy Support:
It prevents fetal neural tube defects (NTDs) and is unaffected by MTHFR gene polymorphisms, offering an absorption rate far superior to that of ordinary folic acid.
Promotion of Neurotransmitter Synthesis:
It facilitates the synthesis of serotonin, dopamine, and norepinephrine, helping to improve mood and cognitive health. (This action supports the research and development of formulations for mood balance and cognitive health.)
High Bioavailability: As a "ready-to-use" form of folate, it bypasses liver metabolic conversion and enters the bloodstream directly upon intake.
It effectively addresses the MTHFR enzyme activity deficiency that affects approximately 30%-50% of the global population.
It prevents the accumulation of unmetabolized folic acid (UMFA) in the serum, thereby avoiding the risk of masking vitamin B12 deficiency.
The crystalline form ensures excellent chemical stability at room temperature, making it suitable for processing into tablets, capsules, and solid beverages.
The CAS number of L-5-MTHF (L-Methylfolate Calcium) is 151533-22-1.
AIDU Biotech supplies L-5-MTHF (L-Methylfolate Calcium) at 95.0%~102.0%, with full analytical data and a Certificate of Analysis (COA) for every batch.
Yes. Every batch of L-5-MTHF ships with a complete Certificate of Analysis (COA), and we provide MSDS and third-party test reports on request.
Yes. AIDU Biotech keeps inventory in our Los Angeles, USA warehouse for faster North American delivery, alongside global shipping from our own manufacturing facility.
MOQ and bulk pricing vary by grade and volume. Contact idusc@aidubio.com for free samples and a quote.
Tell us the ingredient and volume you need. Our team will respond with pricing, lead time and documentation.
