The bioactive folate form — direct absorption without MTHFR conversion
L-5-Methyltetrahydrofolate Calcium (L-5-MTHF-Ca) is the primary bioactive form of folate in the human body. It directly participates in the one-carbon metabolism cycle without requiring conversion by the MTHFR enzyme.
Thanks to its high bioavailability and suitability for individuals with MTHFR variants, L-5-MTHF has become a core ingredient in the fields of maternal and infant nutrition, cardiovascular health, mood management, and functional foods.
As a direct manufacturer, Shanghai Aidu Biotechnology Co., Ltd. provides high-purity L-5-MTHF-Ca raw material powder specifically for global dietary supplement brands, nutraceutical OEM manufacturers, and formulation scientists. It offers the same active ingredient with more competitive factory-direct pricing.
| Test Items | Specifications |
|---|---|
| Assay(on dry basis) | 95.0%~102.0% |
| L-5-MTHF | 72.0%~87.0% |
| Calcium(on dry basis) | 7.0%~8.5% |
| Water Content | 6.0%-17.0% |
| Platinum | 10ppm Max |
| Boron | 30ppm Max |
| Chloride | 0.5%Max |
| Heavy Metals | 10ppm Max |
| Pb | 0.5ppm Max |
| As | 0.5ppm Max |
| Hg | 0.1ppm Max |
| Cd | 0.5ppm Max |
| Total Plate Count | 1000cfu/g Max |
| Mold & Yeast | 100cfu/g Max |
As the most biologically active form of folate, L-5-Methyltetrahydrofolate Calcium delivers significant synergistic effects when combined with other nutrients. Below are typical formulation recommendations widely adopted in the market:
Directly prevents fetal neural tube defects; ensures efficient blood formation and alleviates anemia during pregnancy.
Synergistically lowers homocysteine (Hcy) levels to prevent stroke and hypertension.
Boosts the synthesis of serotonin and dopamine, aids in anti-depression, and protects cognitive function in the elderly.
Safeguards sperm DNA integrity and enhances sperm quality and vitality.
Provides deep support for DNA repair and methylation balance, boosting cellular energy from the source.
Packaging Specifications: 1kg/aluminum foil bag, 5kg/aluminum foil bag, 25kg/fiber drum; packaging specifications can be customized according to customer requirements.
Storage Conditions: Keep sealed, protected from light, in a low-temperature, dry (recommended 2–8°C), and well-ventilated place.
Shelf Life: 24 months
We are a global leader in L-5-MTHF-Ca (Active Folate) manufacturing, dedicated to women’s health, prenatal nutrition, and metabolic regulation. Leveraging advanced biotransformation and purification, we provide premium raw materials for the global nutraceutical and pharmaceutical industries.
AIDU Biotech, a direct source factory, supplies high-purity active ingredients, with rapid delivery from US warehouses, empowering global women's health brands.
L-5-MTHF-Ca is CAS 151533-22-1 (C₂₀H₂₃CaN₇O₆, MW 497.52). Assay is 95.0%~102.0% on a dry basis with L-5-MTHF content of 72.0%~87.0% and calcium at 7.0%~8.5%.
L-5-MTHF is the primary bioactive folate form and enters the one-carbon cycle directly without requiring MTHFR enzyme conversion, making it suitable for consumers carrying MTHFR variants.
We are a direct source manufacturer with full closed-loop GMP control from raw materials to packaging, supported by FSSC22000 / HALAL / KOSHER certifications — which removes middleman markups and secures long-term spot supply.
Keep sealed and light-protected at a recommended 2–8°C; shelf life 24 months. Packaging is 1 kg, 5 kg aluminum foil bags or 25 kg fiber drums. Rapid delivery is available from our Los Angeles, CA warehouse — contact idusc@aidubio.com for MOQ and pricing.
Tell us the ingredient and volume you need. Our team will respond with pricing, lead time and documentation.
