Acacetin

Acacetin

Natural Aromatase Inhibitor · Men's Health Support · Innovative Ingredient for Sports Nutrition and Metabolic Management

CAS Number: 480-44-4
Molecular Formula: C16H12O5
Molecular Weight: 284.26
Appearance: Pale yellow to yellow crystalline powder

01Product Description

As demand continues to grow in the global dietary supplement market for “natural hormone balance,” “sports recovery,” “healthy aging,” and “metabolic management,” traditional synthetic hormone-regulating ingredients are increasingly facing challenges due to safety concerns and regulatory restrictions. As a high-purity flavonoid compound derived from natural plants, Acacetin has garnered significant attention in recent years within the international sports nutrition, men’s health, weight management, and healthy aging sectors.

Given its research potential in aromatase inhibition, antioxidant activity, anti-inflammatory effects, metabolic support, and male hormone health management, Acacetin has gradually emerged as a leading ingredient in the next generation of natural sports nutrition ingredients and functional dietary supplements.

02Product Specifications

Test ItemSpecification StandardTest Method
Assay98.0% MinHPLC-AREA
Loss on drying1.0% MaxUSP
IdentificationSimilar to working standardHPLC
Heavy metals10ppm MaxUSP
As1.0ppm MaxICP-MS
Pb1.0ppm MaxICP-MS
Cd1.0ppm MaxICP-MS
Hg1.0ppm MaxICP-MS
Residue on ignition0.20% MaxUSP
Total Plate Count1000 cfu/g MaxGB4789.2-2022
Yeast & Mold100 cfu/g MaxGB4789.15-2016 I

03Product Advantages

Fully Synthetic Precision Manufacturing Process

We employ an advanced fully synthetic precision manufacturing process that combines multi-step purification with precision recrystallization technology. This eliminates risks associated with plant-derived pesticide residues, unknown impurities, and exogenous heavy metals at the source. It ensures consistent purity of ≥98.0% across batches (with typical batches reaching 99.9%). Production is completely free from seasonal and regional constraints, ensuring a stable supply chain and sufficient production capacity, which provides a solid foundation for stable, large-scale industrial-grade delivery.

High Purity and Excellent Formulation Compatibility

Product purity is consistently maintained at 98.0% or higher. Through a proprietary powder modification process, particle size is strictly controlled. The powder exhibits excellent flowability, moisture resistance, and low bitterness. With low static charge and minimal tendency to adhere to walls, it is perfectly suited for the processing and development of various complex dosage forms, including hard capsule filling, tableting, solid beverage powders, functional gummies, and ready-to-drink (RTD) liquid beverages.

Quality Control and International Compliance Support

Production and quality control systems strictly adhere to international pharmacopoeia standards. For the fully synthetic process, solvent residue control fully complies with the limit requirements of USP <467> / EP. We maintain a comprehensive compliance documentation library and can quickly provide contracted clients with Non-GMO Declarations, Allergen-Free Certificates, BSE/TSE-Free Certificates, and complete batch COAs, significantly shortening the compliance approval cycle for your new products in overseas markets.

04Product Functions

Natural Aromatase Inhibitors and Testosterone Support

In recent years, Acacetin has garnered significant attention in the international market for men’s vitality and non-hormonal muscle support due to its outstanding research data in the field of aromatase inhibition. It is widely used in the development of cutting-edge formulations for high-end professional testosterone support, post-cycle therapy (PCT), and daily performance enhancement for men.

Metabolic Management, Thermogenesis, Fat Burning, and Lean Muscle

Multiple lines of scientific research indicate that Acacetin is closely associated at the cellular level with fatty acid oxidation, exercise metabolism regulation, and skeletal muscle energy utilization. This makes it a key differentiating ingredient in innovative sports nutrition products, including stimulant-free weight management formulas, high-efficiency thermogenic fat-burning products, and formulations designed to maintain lean muscle mass.

Cellular Health and Anti-Aging

As a highly active natural flavonoid functional ingredient, Acacetin is closely linked to fundamental scientific research on regulating the NF-κB pathway, balancing oxidative stress, and maintaining healthy inflammatory responses in the body. This provides broad scope for innovation in its application within formulations for healthy aging, mitochondrial support, and premium comprehensive daily wellness nutrition.

05Applications

Given the promising results demonstrated by acacetin in basic scientific research, the recommended single-dose addition for its formulations is typically 25 mg to 100 mg. Thanks to its process advantages of low dosage requirements and high stability, this ingredient can be seamlessly integrated into the following four major international high-end B2B product lines:

  • Men’s Health and Testosterone Support: Natural testosterone boosters, post-workout recovery (PCT) support, male performance enhancement, and vegan/non-hormonal lean muscle maintenance products.

Formulations: Capsules / Tablets / Blended Powders

  • Sports Nutrition and Lean Muscle Building: Suitable for lean muscle building, post-workout recovery, performance enhancement, and the development of high-intensity sports nutrition products.

Formulations: Instant Powders / Capsules / RTD (Ready-to-Drink) Functional Beverages

  • Metabolic Management & Thermogenic Fat Burning: Caffeine-free/stimulant-free thermogenic fat burners, premium weight management solutions, and products supporting daily basal metabolic rate (BMR).

Formulations: Capsules / Powder Sachets / Functional Beverages

  • Healthy Aging and Antioxidant Support: Suitable for the development of products supporting healthy aging, cellular health, antioxidant support, and longevity nutrition.

Formulations: Capsules / Tablets / Functional Powders

06Formulation Considerations

Professional-Grade Male Vitality and Testosterone-Boosting Matrix

  • Recommended Combination: Acacetin + Tongkat Ali + ZMA + Black Pepper Extract / Piperine 95%
  • Applications: Testosterone Boosting / Male Performance Optimization / Post-Workout Recovery (PCT) Support
  • Formulation Features: Tailored specifically for men’s health and sports nutrition products, this blend synergizes with popular testosterone-supporting ingredients on the market to enhance overall formulation efficacy.

Thermogenic & Lean Muscle Formula

  • Recommended Combination: Acacetin + Paraxanthine + EGCG + L-Carnitine
  • Applications: Thermogenesis / Weight Management / Lean Muscle Building
  • Formula Features: Tailored for body recomposition and clean energy formulations, precisely addressing the modern sports nutrition market’s urgent need for low-stimulation metabolic support products.

Cellular Health & Longevity Support

  • Recommended Combination: Acacetin + RejuEGT® + Coenzyme Q10
  • Applications: Cellular Longevity Management / Daily Antioxidant Support / Oral Beauty & Anti-Aging / Gentle Cellular Energy
  • Formulation Features: Acacetin combines with our proprietary high-purity anti-aging ingredient, L-Ergothioneine (RejuEGT®), to balance oxidative stress through multiple pathways, scavenge free radicals, and maintain youthful vitality at the cellular and mitochondrial levels.

07Packaging & Storage

Packaging specifications: 1 kg / aluminum foil bag, standard 25 kg / cardboard drum (lined with a double-layer moisture-proof PE bag); small-batch custom orders for pilot testing and R&D are available.

Storage conditions: Keep tightly sealed and store in a cool, dry, well-ventilated area away from light, heat, and moisture.

Shelf life: 24 months.

08Frequently Asked Questions

What is the CAS number and typical purity?

Acacetin is CAS 480-44-4, molecular formula C16H12O5, molecular weight 284.26. Specification is ≥98.0% by HPLC, with typical batches reaching 99.9%.

Is your acacetin plant-extracted or synthetic?

It is produced by a fully synthetic precision process with multi-step purification and recrystallization, which removes the risk of plant-derived pesticide residues and unknown impurities and makes supply independent of seasonal or regional constraints.

What is the recommended dosage in a finished formulation?

Based on published research, the typical single-dose addition is 25 mg to 100 mg per serving, adjusted to product positioning.

Which compliance documents can you provide?

Non-GMO declarations, allergen-free certificates, BSE/TSE-free certificates and complete batch COAs; residual solvents comply with USP <467> / EP limits. Contact idusc@aidubio.com for documentation, MOQ and U.S. warehouse (Los Angeles, CA) delivery.

GET IN TOUCH

Request a quote or sample

Tell us the ingredient and volume you need. Our team will respond with pricing, lead time and documentation.

+86-21-61049330 · +86-138-1774-6068
idusc@aidubio.com
Warehouse Address: Los Angeles, CA, USA

Tell us what you need

We use your details only to respond to this enquiry.