Epicatechin is a naturally occurring flavanol-class polyphenol compound, widely present in green tea, cocoa, and a variety of plant-based foods. It stands as a representative bioactive component within the tea polyphenol system. As the naturally existing (-)-Epicatechin configuration, its efficacy in areas including muscle metabolism, antioxidant activity, vascular health, and cell signal regulation has been validated by extensive research.
| Test Item | Specification | Method |
|---|---|---|
| Assay | 91.7% Min | HPLC |
| Caffeine | 0.0% Max | HPLC |
| Loss on drying | 0.3% Max | USP |
| Ash | 0.1% Max | USP |
| Sieve analysis | 95% pass 40 mesh | USP |
| Pb | 1.0ppm Max | ICP-MS |
| As | 1.0ppm Max | ICP-MS |
| Microbiology Control | ||
| Total Plate Count | 1000cfu/g Max | USP |
| Yeast&Mold | 100cfu/g Max | USP |
Sourced from green tea leaves, the product is obtained through extraction and refining processes precisely controlled by physical and solvent methods. This ensures the product retains the naturally occurring (-)-Epicatechin configuration, aligning with the application trends of natural extracts in the international market.
Through multi-step purification and fine separation techniques, the Epicatechin content is stably maintained at ≥90%, facilitating precise formula design and consistency in functional claims.
With a fineness of 95% passing through a 40-mesh sieve, the powder is stable and easy to process, making it suitable for various dosage forms such as hard capsule filling, tablet pressing, and powder mixing.
Caffeine is strictly controlled to significantly reduce the risk of irritation, making it ideal for sports nutrition, healthy aging, and long-term consumption products.
The product is manufactured entirely at AIDU Biotech's own production base, with the production system adhering to cGMP quality management standards. The raw materials meet Non-GMO, Solvent-free, and Gluten-free requirements. Each batch undergoes comprehensive physical-chemical and microbial testing, ensuring compliance for entry into mainstream markets such as the US and the EU.
For the first time, research has demonstrated in human populations that (-)-Epicatechin can participate in the regulation of skeletal muscle growth and differentiation by downregulating Myostatin expression and upregulating related regulatory factors such as Follistatin, which is associated with improved muscle strength.
Epicatechin has been found to influence signaling pathways related to mitochondrial function and oxidative metabolism, showing potential application value in supporting athletic performance and metabolic health.
As a natural flavanol, Epicatechin can integrate into the body's antioxidant defense system and activate endothelial nitric oxide synthase (eNOS), promoting the release of nitric oxide (NO). This mechanism contributes to vasodilation, improves hemodynamics, and provides robust support for cardiovascular health.
,Myostatin Inhibition and Muscle Strength Enhancement (Human Study)In a 2014 study published in the Journal of Nutritional Biochemistry, Gutierrez-Salmeán et al. were the first to demonstrate in human populations that (-)-Epicatechin can significantly reduce serum Myostatin levels and improve the grip strength of subjects, providing key scientific support for its application in the fields of muscle health and sports nutrition.
Differences observed in SkM growth/differentiation and SA-β-Gal protein levels in young and old control or (−)-epicatechin treated mice. Panel A shows Western blot images observed in myostatin, follistatin, MEF2A, Myf5, MyoD, myogenin. Panel B plots the mean ± SEM densitometric units of the protein of interest normalized over GAPDH values. Panel C denotes differences observed in senescence associated-β-Gal protein levels. (n=5/group).
Differences observed in markers of muscle growth, in older vs. young human subjects, and effects of 1 week (−)-epicatechin treatment on strength and SkM growth markers in middle age subjects. Panel A shows Western blot images for myostatin, follistatin, MEF2A, Myf5, MyoD, myogenin protein levels in human quadriceps from young vs. old subjects. Panel B plots the mean ± SEM densitometric units of the protein of interest normalized over GAPDH values. Panel C denotes differences observed in senescence associated-β-Gal protein levels. (n=5/group).
https://pubmed.ncbi.nlm.nih.gov/24314870/; https://doi.org/10.1016/j.jnutbio.2013.09.007;
,Epicatechin and Molecular Regulatory Mechanisms in Skeletal MuscleThe study also demonstrates that Epicatechin can modulate multiple molecular signaling pathways associated with skeletal muscle growth and differentiation, lending robust support to the scientific rationale for its use as a muscle function nutrient.*Reference: https://www.sciencedirect.com/science/article/pii/S0955286313002076
The CAS number of Green Tea Extract Epicatechin 90% Min HPLC is 490-46-0.
AIDU Biotech supplies Green Tea Extract Epicatechin 90% Min HPLC at 91.7% Min, with full analytical data and a Certificate of Analysis (COA) for every batch.
Yes. Every batch of Green Tea Extract Epicatechin 90% Min HPLC ships with a complete Certificate of Analysis (COA), and we provide MSDS and third-party test reports on request.
Yes. AIDU Biotech keeps inventory in our Los Angeles, USA warehouse for faster North American delivery, alongside global shipping from our own manufacturing facility.
MOQ and bulk pricing vary by grade and volume. Contact idusc@aidubio.com for free samples and a quote.
Tell us the ingredient and volume you need. Our team will respond with pricing, lead time and documentation.
